Welcome to John Schimenti's Lab at Cornell University in Ithaca, NY.
Our lab investigates the genetics and mechanisms of gametogenesis, meiosis, and genome maintenance. In particular, we focus on role of genes that are important for: 1) germ cell formation and fertility; 2) cancer prevention; and 3) avoidance of mutations that would cause developmental defects in offspring. We used the mouse as a model system to modify and mutate orthologs of human genes, using genome editing and transgenic technologies such as CRISPR. See “Projects” tab for more details.
